Banca de DEFESA: ISAIAS LOPES

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ISAIAS LOPES
DATE: 11/04/2025
TIME: 08:30
LOCAL: https://meet.google.com/his-gujt-iba,
TITLE:

PAIN PHENOTYPE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: A

CROSS-SECTIONAL STUDY

KEY WORDS:

 Lupus Erythematosus, Systemic; Chronic Pain; Central Nervous System
Sensitization.

PAGES: 55
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

I

Introduction: Systemic Lupus Erythematosus (SLE) is an autoimmune disease that promotes
chronic systemic inflammation caused by production of autoantibodies and deposition of
immune complexes into different organs and structures, with a period of activation and
remission. Objective: To describe the phenotype of chronic pain in patients with SLE in
Brazil, considering regional distributions and associated psychosocial factors. Material and
methods: This observational cross-sectional study will have as inclusion criteria: individuals
aged over 18 years of both genders diagnosed with SLE; presence of pain for at least 3
months; and as exclusion criteria: individuals with another type of lupus (cutaneous or
induced by medication); people without pain in the last 3 months. Results: The study sample
consisted of 142 individuals diagnosed with Systemic Lupus Erythematosus, from the North,
Northeast, Southeast, South and Central-West regions of Brazil. Most participants were
single, of mixed race, and had completed high school. Regarding clinical aspects, it was found
that the average pain intensity was moderate and that most participants used, on average, three
medications. Final Considerations: The chronic pain phenotype in SLE patients in Brazil is
multifactorial, and is related to a central sensitization process, in addition to psychosocial
factors such as fatigue and anxiety, and neuropathic components.
Keywords: Lupus Erythematosus, Systemic; Chronic Pain; Central Nervous System
Sensitization.

COMMITTEE MEMBERS:
Interno - 2032907 - AREOLINO PENA MATOS
Interno - 3283051 - DIEGO BULCAO VISCO
Externo à Instituição - HELISON DE OLIVEIRA CARVALHO - UNIFAP
Presidente - 3066678 - NATALIA CAMARGO RODRIGUES IOSIMUTA