Banca de DEFESA: ROBERTA FREITAS FRAZAO

Uma banca de DEFESA de MESTRADO foi cadastrada pelo programa.
STUDENT : ROBERTA FREITAS FRAZAO
DATE: 23/05/2025
TIME: 10:30
LOCAL: https://meet.google.com/yci-bqhb-yer
TITLE:

EPIDEMIOLOGICAL CHARACTERIZATION OF BLOOD DONORS UNFIT
DUE TO HEPATITIS C VIRUS IN A BLOOD CENTER IN THE NORTHERN REGION OF BRAZIL

KEY WORDS:

Keywords: Blood donors. Hepacivirus. Blood Safety. Hemotherapy.

PAGES: 81
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Serological testing for the hepatitis C virus (HCV) in blood donors is essential for transfusion
safety, given the asymptomatic nature of the infection in its early stages. In this context, the
present study aimed to analyze the epidemiological profile of blood donors with reactive
serology for HCV who were attended at the Hematology and Hemotherapy Institute of Amapá

(HEMOAP) from January 2019 to December 2023. This is a cross-sectional, analytical-
retrospective study, conducted through the collection of secondary data from a computerized

database. Data were extracted from the Hemotherapy Units Management System
(HEMOVIDA) and analyzed using the JAMOVI statistical software, version 2.4.11.
Information was organized according to variables such as sex, age group, marital status, and
educational level. To evaluate the relationship between the number of donors deemed unfit due
to HCV and time (in years), Pearson’s correlation coefficient was used. Additionally, Fisher’s
Exact Test was applied to analyze associations between categorical variables. All analyses
considered a 95% significance level (p < 0.05). During the analyzed period, HEMOAP
registered 70,606 blood donation candidates. Of these, 1,972 (2.79%) were considered unfit
during laboratory screening due to reactive serological markers. Among the unfit donors, 75
showed reactive serology for hepatitis C. Of these, the majority were male, totaling 39 cases
(52.0%); 46 (61.33%) were single; 31 (41.33%) had completed higher education; and most,

corresponding to 81.33%, resided in the city of Macapá. A reduction was observed in the HCV-
related unfitness rate among blood donors at HEMOAP. Clinical ineligibility analysis revealed

anemia, risky sexual behavior, and low hematocrit as the main impediments to blood donation.
In the case of serological ineligibility due to HCV, a higher prevalence was observed among
male, young, and single individuals. The identification of these cases reinforces the strategic
role of blood centers as sentinel sites for the detection of infectious diseases, especially those
with an asymptomatic course, such as hepatitis C.
Keywords: Blood donors. Hepacivirus. Blood Safety. Hemotherapy.

COMMITTEE MEMBERS:
Externa à Instituição - LUISA CARICIO MARTINS
Presidente - 2039588 - AMANDA ALVES FECURY
Interno - 1539559 - DEMILTO YAMAGUCHI DA PUREZA
Interna - 326748 - ROSEMARY FERREIRA DE ANDRADE