Banca de QUALIFICAÇÃO: PATRICIA NATALIA BARBOSA DA SILVA

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : PATRICIA NATALIA BARBOSA DA SILVA
DATE: 25/02/2025
TIME: 15:00
LOCAL: BLOCO DE PÓS-GRADUAÇÃO
TITLE:

AVALIAÇÃO in silico E in vitro DE ATIVIDADE BIOLÓGICA DO ÓLEO-RESINA DA
Copaifera reticulata DUCKE SOBRE A COAGULAÇÃO SANGUÍNEA

KEY WORDS:

Coagulation; Fabaceae; molecular docking; Oleoresin.

PAGES: 64
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

The study evaluated the resin oil from the plant Copaifera reticulata Ducke, belonging
to the Fabaceae family, investigating its possible anticoagulant activity in human
plasma. The objective was to analyze whether the resin oil interfered with the
coagulation cascade through laboratory studies and molecular modeling. The research
employed tests conducted with human plasma subjected to different concentrations of
the resin oil, analyzing the time required for clot formation, considering prothrombin
time (PT) and activated partial thromboplastin time (APTT). The data obtained were
subjected to statistical analysis to verify the significance of the results. Simultaneously,
molecular modeling identified chemical compounds present in the resin oil with
favorable characteristics for interacting with targets related to blood coagulation,
comparing them to known anticoagulant drugs. The results indicated a low
anticoagulant effect in laboratory tests with human plasma, while computational
analysis suggested that certain specific compounds, such as beta-caryophyllene and
bicyclogermacrene, exhibited properties that could contribute to anticoagulant activity.

The research, still in progress, seeks to understand the potential of resin oil as a plant-
based alternative with anticoagulant properties.

COMMITTEE MEMBERS:
Presidente - 2070112 - MADSON RALIDE FONSECA GOMES
Interno - 2233748 - ALEX BRUNO LOBATO RODRIGUES
Externo ao Programa - 1586732 - CLEYDSON BRENO RODRIGUES DOS SANTOS - UNIFAP