Banca de QUALIFICAÇÃO: RICHELLE BARBOZA BARROS

Uma banca de QUALIFICAÇÃO de MESTRADO foi cadastrada pelo programa.
STUDENT : RICHELLE BARBOZA BARROS
DATE: 31/10/2024
TIME: 08:40
LOCAL: BLOCO DA PÓS GRADUAÇÃO
TITLE:

Interleukin-6 expression profile in people with periodontal disease and
diabetes mellitus.

KEY WORDS:

Diabetes; Periodontitis; Cytokines.

PAGES: 54
BIG AREA: Ciências da Saúde
AREA: Saúde Coletiva
SUMMARY:

Periodontal disease and diabetes mellitus are considered to be bidirectional
pathologies, since hyperglycemia raises the concentration of glucose and urea in the
oral cavity, altering the constitution of dental plaque and thus stimulating the growth of
some species of bacteria, while the inflammatory mediators of periodontal disease can
cause insulin resistance, fostering the interrelationship between the two conditions. In
addition, the expression of these pro-inflammatory cytokines can increase significantly
as there is a decrease in immune capacity and an increase in the inflammatory
response. To analyze the expression of interleukin-6 in individuals with periodontal
disease and diabetes mellitus, using a quantitative approach; the results of 20
participants were analyzed, where the average IL-6 level was 9.275 pg/ml, 20% had
stage I periodontitis, 50% stage II, 5% stage III and 25% stage IV and that these were
directly influenced by the time of diagnosis of DM, in addition, there was no strong
association between the variables presence of periodontitis, degree of periodontitis
and IL-6 dosage and Pearson's p-value showed no correlation between the variables
investigated. Recognizing the direct influence of periodontal disease on the increased
expression of interleukin-6 in patients with DM requires continued data collection.
However, through the partial results, it was observed that the time of diagnosis of DM
significantly influences the stage of PD, which is why it is extremely important to be
monitored by a dental surgeon in order to avoid the development of oral pathologies.
Keywords: Diabetes; Periodontitis; Cytokines.

COMMITTEE MEMBERS:
Presidente - 1432793 - MARIA IZABEL CORTES VOLPE
Interna - 1014420 - FRANCINEIDE PEREIRA DA SILVA PENA
Externo à Instituição - GEORGE HARRISON FERREIRA DE CARVALHO